Single daily dosing of antibiotics: importance of in vitro killing rate, serum half-life, and protein binding.

The relative importance of pharmacokinetic and pharmacodynamic parameters for the feasibility of a single daily dose (SDD) of antibiotics remains to be established. Therefore, we studied the relationship between in vitro bacteriological parameters (MIC, MBC, and killing rate [KR], defined as the red...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Potel, G, Chau, N P, Pangon, B, Fantin, B, Vallois, J M, Faurisson, F, Carbon, C
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1991
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC245330/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1759831/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.35.10.2085
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