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Identification and Rational Redesign of Peptide Ligands to CRIP1, A Novel Biomarker for Cancers

Cysteine-rich intestinal protein 1 (CRIP1) has been identified as a novel marker for early detection of cancers. Here we report on the use of phage display in combination with molecular modeling to identify a high-affinity ligand for CRIP1. Panning experiments using a circularized C7C phage library...

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Detalhes bibliográficos
Main Authors: Hao, Jihua, Serohijos, Adrian W. R., Newton, Gail, Tassone, Gina, Wang, Zuncai, Sgroi, Dennis C., Dokholyan, Nikolay V., Basilion, James P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2453235/
https://ncbi.nlm.nih.gov/pubmed/18670594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000138
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