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Functional and Mechanistic Analyses of Biomimetic Aminoacyl Transfer Reactions in de novo Designed Coiled Coil Peptides via Rational Active Site Engineering

Ribosomes and nonribosomal peptide synthetases (NRPSs) carry out instructed peptide synthesis through a series of directed intermodular aminoacyl transfer reactions. We recently reported the design of coiled-coil assemblies that could functionally mimic the elementary aminoacyl loading and intermodu...

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Autors principals: Leman, Luke J., Weinberger, Dana A., Huang, Zheng-Zheng, Wilcoxen, Keith M., Ghadiri, M. Reza
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2453064/
https://ncbi.nlm.nih.gov/pubmed/17302417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja068052x
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