In vitro and in vivo potentiation of chloroquine against malaria parasites by an enantiomer of amlodipine.

A combination of chloroquine and amlodipine, a derivative of 1,4-dihydropyridine calcium channel blocker, was tested against Plasmodium falciparum in vitro and P. yoelii in mice. The dextrorotary enantiomer of amlodipine, practically devoid of calcium channel blocking action, increased chloroquine a...

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Udgivet i:	Antimicrob Agents Chemother
Principais autores:	Deloron, P, Basco, L K, Dubois, B, Gaudin, C, Clavier, F, Le Bras, J, Verdier, F
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1991
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC245168/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1834011/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.35.7.1338
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