In vitro and in vivo potentiation of chloroquine against malaria parasites by an enantiomer of amlodipine.

A combination of chloroquine and amlodipine, a derivative of 1,4-dihydropyridine calcium channel blocker, was tested against Plasmodium falciparum in vitro and P. yoelii in mice. The dextrorotary enantiomer of amlodipine, practically devoid of calcium channel blocking action, increased chloroquine a...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Deloron, P, Basco, L K, Dubois, B, Gaudin, C, Clavier, F, Le Bras, J, Verdier, F
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC245168/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1834011/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.35.7.1338
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