5'-Alkyl-substituted analogs of 5'-methylthioadenosine as trypanocides.

5'-Deoxy-5'-(methylthio)adenosine (MTA) is a by-product of polyamine metabolism and is phosphoryolytically cleaved to adenine and 5-deoxy-5-(methylthio)ribose-1-phosphate (MTR-1-P) by MTA phosphorylase. In eukaryotes, adenine is subsequently salvaged and converted to nucleotides, while MTR...

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Detalhes bibliográficos
Main Authors: Bacchi, C J, Sufrin, J R, Nathan, H C, Spiess, A J, Hannan, T, Garofalo, J, Alecia, K, Katz, L, Yarlett, N
Formato: Artigo
Idioma:Inglês
Publicado em: 1991
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC245164/
https://ncbi.nlm.nih.gov/pubmed/1929287
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