In vivo efficacies of 5'-methylthioadenosine analogs as trypanocides.

5'-Deoxy-5'-(methylthio)adenosine (MTA), a key by-product of polyamine biosynthesis, is cleaved by MTA phosphorylase and is salvaged as adenine and, through conversion of the ribose moiety, methionine. An analog of MTA, 5'-deoxy-5'-(hydroxyethylthio)adenosine (HETA), is a substra...

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Autors principals: Bacchi, C J, Sanabria, K, Spiess, A J, Vargas, M, Marasco, C J, Jimenez, L M, Goldberg, B, Sufrin, J R
Format: Artigo
Idioma:Inglês
Publicat: 1997
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC164078/
https://ncbi.nlm.nih.gov/pubmed/9333033
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