Pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-deoxy-2',3'-didehydrothymidine in rats.

Concentrations of 3'-fluoro-3'-deoxythymidine (FDT) and 3'-deoxy-2',3'-didehydrothymidine (D4T) in plasma declined in a biexponential fashion. Total clearance of D4T (1.75 +/- 0.22 liters/h/kg; mean +/- standard deviation) was significantly greater than that of FDT (1.19 +/- 0.19 liters/h/kg) owing...

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Detalles Bibliográficos

Publicado en:	Antimicrob Agents Chemother
Principais autores:	Boudinot, F D, Smith, S G, Funderburg, E D, Schinazi, R F
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 1991
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC245090/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1648888/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.35.4.747
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