Pharmacokinetics of 3'-azido-3'-deoxythymidine and its catabolites and interactions with probenecid in rhesus monkeys.

The pharmacokinetics and metabolism of 3'-azido-3'-deoxythymidine (AZT) were investigated in rhesus monkeys after subcutaneous administration of 33.3 mg of AZT per kg of body weight alone or in the presence of 100 mg of probenecid per kg. In addition to unchanged drug, two catabolites, 5'-O-glucuron...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Cretton, E M, Schinazi, R F, McClure, H M, Anderson, D C, Sommadossi, J P
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1991
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC245110/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1854160/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.35.5.801
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