Pharmacokinetics of 3'-azido-3'-deoxythymidine and its catabolites and interactions with probenecid in rhesus monkeys.

The pharmacokinetics and metabolism of 3'-azido-3'-deoxythymidine (AZT) were investigated in rhesus monkeys after subcutaneous administration of 33.3 mg of AZT per kg of body weight alone or in the presence of 100 mg of probenecid per kg. In addition to unchanged drug, two catabolites, 5'-O-glucuron...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Cretton, E M, Schinazi, R F, McClure, H M, Anderson, D C, Sommadossi, J P
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC245110/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1854160/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.35.5.801
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