The FACT Spt16 “peptidase” domain is a histone H3–H4 binding module

The FACT complex is a conserved cofactor for RNA polymerase II elongation through nucleosomes. FACT bears histone chaperone activity and contributes to chromatin integrity. However, the molecular mechanisms behind FACT function remain elusive. Here we report biochemical, structural, and mutational a...

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Hlavní autoři: Stuwe, Tobias, Hothorn, Michael, Lejeune, Erwan, Rybin, Vladimir, Bortfeld, Miriam, Scheffzek, Klaus, Ladurner, Andreas G.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2449335/
https://ncbi.nlm.nih.gov/pubmed/18579787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712293105
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