The FACT Spt16 “peptidase” domain is a histone H3–H4 binding module

The FACT complex is a conserved cofactor for RNA polymerase II elongation through nucleosomes. FACT bears histone chaperone activity and contributes to chromatin integrity. However, the molecular mechanisms behind FACT function remain elusive. Here we report biochemical, structural, and mutational a...

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Bibliographic Details
Main Authors: Stuwe, Tobias, Hothorn, Michael, Lejeune, Erwan, Rybin, Vladimir, Bortfeld, Miriam, Scheffzek, Klaus, Ladurner, Andreas G.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2449335/
https://ncbi.nlm.nih.gov/pubmed/18579787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712293105
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