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Infused Fc-tagged β-glucuronidase crosses the placenta and produces clearance of storage in utero in mucopolysaccharidosis VII mice

Glycosaminoglycan storage begins in prenatal life in patients with mucopolysaccharidosis (MPS). In fact, prenatal hydrops is a common manifestation of MPS VII because of β-glucuronidase (GUS) deficiency. One way to address prenatal storage might be to deliver the missing enzyme across the placenta i...

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Auteurs principaux: Grubb, Jeffrey H., Vogler, Carole, Tan, Yun, Shah, Gul N., MacRae, Amy F., Sly, William S.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2448844/
https://ncbi.nlm.nih.gov/pubmed/18544647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803715105
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