Targeted Depletion of Hepatic ACAT2-driven Cholesterol Esterification Reveals a Non-biliary Route for Fecal Neutral Sterol Loss

Deletion of acyl-CoA:cholesterol O-acyltransferase 2 (ACAT2) in mice results in resistance to diet-induced hypercholesterolemia and protection against atherosclerosis. Recently, our group has shown that liver-specific inhibition of ACAT2 via antisense oligonucleotide (ASO)-mediated targeting likewis...

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Detalhes bibliográficos
Main Authors: Brown, J. Mark, Bell, Thomas A., Alger, Heather M., Sawyer, Janet K., Smith, Thomas L., Kelley, Kathryn, Shah, Ramesh, Wilson, Martha D., Davis, Matthew A., Lee, Richard G., Graham, Mark J., Crooke, Rosanne M., Rudel, Lawrence L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2447638/
https://ncbi.nlm.nih.gov/pubmed/18281279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M707659200
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