Targeted Depletion of Hepatic ACAT2-driven Cholesterol Esterification Reveals a Non-biliary Route for Fecal Neutral Sterol Loss

Deletion of acyl-CoA:cholesterol O-acyltransferase 2 (ACAT2) in mice results in resistance to diet-induced hypercholesterolemia and protection against atherosclerosis. Recently, our group has shown that liver-specific inhibition of ACAT2 via antisense oligonucleotide (ASO)-mediated targeting likewis...

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Bibliografische gegevens
Hoofdauteurs: Brown, J. Mark, Bell, Thomas A., Alger, Heather M., Sawyer, Janet K., Smith, Thomas L., Kelley, Kathryn, Shah, Ramesh, Wilson, Martha D., Davis, Matthew A., Lee, Richard G., Graham, Mark J., Crooke, Rosanne M., Rudel, Lawrence L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2008
Onderwerpen:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2447638/
https://ncbi.nlm.nih.gov/pubmed/18281279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M707659200
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