Cholesteryl Ester Hydroperoxides Are Biologically Active Components of Minimally Oxidized Low Density Lipoprotein

Oxidation of low density lipoprotein (LDL) occurs in vivo and significantly contributes to the development of atherosclerosis. An important mechanism of LDL oxidation in vivo is its modification with 12/15-lipoxygenase (LO). We have developed a model of minimally oxidized LDL (mmLDL) in which native...

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Bibliografiske detaljer
Main Authors: Harkewicz, Richard, Hartvigsen, Karsten, Almazan, Felicidad, Dennis, Edward A., Witztum, Joseph L., Miller, Yury I.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2447632/
https://ncbi.nlm.nih.gov/pubmed/18263582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709006200
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