Cholesteryl Ester Hydroperoxides Are Biologically Active Components of Minimally Oxidized Low Density Lipoprotein

Oxidation of low density lipoprotein (LDL) occurs in vivo and significantly contributes to the development of atherosclerosis. An important mechanism of LDL oxidation in vivo is its modification with 12/15-lipoxygenase (LO). We have developed a model of minimally oxidized LDL (mmLDL) in which native...

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Detalhes bibliográficos
Main Authors: Harkewicz, Richard, Hartvigsen, Karsten, Almazan, Felicidad, Dennis, Edward A., Witztum, Joseph L., Miller, Yury I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2447632/
https://ncbi.nlm.nih.gov/pubmed/18263582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709006200
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