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Elimination of prions by branched polyamines and implications for therapeutics

We report that branched polyamines, including polyamidoamide dendimers, polypropyleneimine, and polyethyleneimine, are able to purge PrP(Sc), the protease-resistant isoform of the prion protein, from scrapie-infected neuroblastoma (ScN2a) cells in culture. The removal of PrP(Sc) by these compounds d...

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Main Authors: Supattapone, Surachai, Nguyen, Hoang-Oanh B., Cohen, Fred E., Prusiner, Stanley B., Scott, Michael R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The National Academy of Sciences 1999
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC24470/
https://ncbi.nlm.nih.gov/pubmed/10588739
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