Elimination of prions by branched polyamines and implications for therapeutics

We report that branched polyamines, including polyamidoamide dendimers, polypropyleneimine, and polyethyleneimine, are able to purge PrP(Sc), the protease-resistant isoform of the prion protein, from scrapie-infected neuroblastoma (ScN2a) cells in culture. The removal of PrP(Sc) by these compounds d...

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出版年:	Proc Natl Acad Sci U S A
主要な著者:	Supattapone, Surachai, Nguyen, Hoang-Oanh B., Cohen, Fred E., Prusiner, Stanley B., Scott, Michael R.
フォーマット:	Artigo
言語:	Inglês
出版事項:	National Academy of Sciences 1999
主題:	Biological Sciences
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24470/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10588739/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.25.14529
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