Spontaneous Amplification of the Actinorhodin Gene Cluster in Streptomyces coelicolor Involving Native Insertion Sequence IS466

We observed a spontaneous amplification of the Streptomyces coelicolor chromosome, including genes encoding biosynthetic enzymes of the antibiotic actinorhodin. A new junction of two tandem segments has, inserted within it, a third copy of a transposable element existing in two places elsewhere in t...

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Bibliographic Details
Main Authors: Widenbrant, E. M., Tsai, Hsiu-Hui, Chen, Carton W., Kao, C. M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
Subjects:
Genetics and Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2446789/
https://ncbi.nlm.nih.gov/pubmed/18441061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00131-08
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