Helicobacter pylori VacA Subdomain Required for Intracellular Toxin Activity and Assembly of Functional Oligomeric Complexes

Helicobacter pylori VacA is a secreted pore-forming toxin that is comprised of two domains, designated p33 and p55. The p55 domain has an important role in the binding of VacA to eukaryotic cell surfaces. A total of 111 residues at the amino terminus of p55 (residues 312 to 422) are essential for th...

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Bibliographic Details
Main Authors: Ivie, Susan E., McClain, Mark S., Torres, Victor J., Algood, Holly M. Scott, Lacy, D. Borden, Yang, Rong, Blanke, Steven R., Cover, Timothy L.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
Subjects:
Molecular Pathogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2446698/
https://ncbi.nlm.nih.gov/pubmed/18443094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01664-07
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