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The Intermediate Region of Helicobacter pylori VacA Is a Determinant of Toxin Potency in a Jurkat T Cell Assay

Colonization of the human stomach with Helicobacter pylori is a risk factor for peptic ulceration, noncardia gastric adenocarcinoma, and gastric lymphoma. The secreted VacA toxin is an important H. pylori virulence factor that causes multiple alterations in gastric epithelial cells and T cells. Seve...

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Detalhes bibliográficos
Main Authors: González-Rivera, Christian, Algood, Holly M. Scott, Radin, Jana N., McClain, Mark S., Cover, Timothy L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434591/
https://ncbi.nlm.nih.gov/pubmed/22585965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00052-12
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