Transgenic Leishmania Model for Delta-Aminolevulinate-Inducible Monospecific Uroporphyria: Cytolytic Phototoxicity Initiated by Singlet Oxygen-Mediated Inactivation of Proteins and Its Ablation by Endosomal Mobilization of Cytosolic Uroporphyrin

Inherent deficiencies of Leishmania in heme biosynthesis were genetically complemented for delta-aminolevulinate-inducible biosynthesis and accumulation of light-excitable uroporphyrin. The phototoxic flagellar immobilization and cytolysis phenotypes and porphyrin mobilization noted previously were...

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Main Authors: Dutta, Sujoy, Kolli, Bala Krishna, Tang, Aihua, Sassa, Shigeru, Chang, Kwang-Poo
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2446678/
https://ncbi.nlm.nih.gov/pubmed/18487349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/EC.00365-07
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