Delta-Aminolevulinate-Induced Host-Parasite Porphyric Disparity for Selective Photolysis of Transgenic Leishmania in the Phagolysosomes of Mononuclear Phagocytes: a Potential Novel Platform for Vaccine Delivery

Leishmania double transfectants (DTs) expressing the 2nd and 3rd enzymes in the heme biosynthetic pathway were previously reported to show neogenesis of uroporphyrin I (URO) when induced with delta-aminolevulinate (ALA), the product of the 1st enzyme in the pathway. The ensuing accumulation of URO i...

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Bibliographic Details
Main Authors: Dutta, Sujoy, Chang, Celia, Kolli, Bala Krishna, Sassa, Shigeru, Yousef, Malik, Showe, Michael, Showe, Louise, Chang, Kwang-Poo
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318301/
https://ncbi.nlm.nih.gov/pubmed/22307976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/EC.05202-11
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