Use of an In Vitro Pharmacodynamic Model To Derive a Linezolid Regimen That Optimizes Bacterial Kill and Prevents Emergence of Resistance in Bacillus anthracis

Simulating the average non-protein-bound (free) human serum drug concentration-time profiles for linezolid in an in vitro pharmacodynamic model, we characterized the pharmacodynamic parameter(s) of linezolid predictive of kill and for prevention of resistance in Bacillus anthracis. In 10-day dose-ra...

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Bibliografiset tiedot
Päätekijät: Louie, A., Heine, H. S., Kim, K., Brown, D. L., VanScoy, B., Liu, W., Kinzig-Schippers, M., Sörgel, F., Drusano, G. L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology (ASM) 2008
Aiheet:
Susceptibility
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2443924/
https://ncbi.nlm.nih.gov/pubmed/18458134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01439-07
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