Use of an In Vitro Pharmacodynamic Model To Derive a Moxifloxacin Regimen That Optimizes Kill of Yersinia pestis and Prevents Emergence of Resistance

Yersinia pestis, the causative agent of bubonic, septicemic, and pneumonic plague, is classified as a CDC category A bioterrorism pathogen. Streptomycin and doxycycline are the “gold standards” for the treatment of plague. However, streptomycin is not available in many countries, and Y. pestis isola...

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Main Authors: Louie, A., Heine, H. S., VanScoy, B., Eichas, A., Files, K., Fikes, S., Brown, D. L., Liu, W., Kinzig-Schippers, M., Sörgel, F., Drusano, G. L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2011
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028806/
https://ncbi.nlm.nih.gov/pubmed/21115791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00818-10
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