Evaluation of Imipenem for Prophylaxis and Therapy of Yersinia pestis Delivered by Aerosol in a Mouse Model of Pneumonic Plague

It has been previously shown that mice subjected to an aerosol exposure to Yersinia pestis and treated with β-lactam antibiotics after a delay of 42 h died at an accelerated rate compared to controls. It was hypothesized that endotoxin release in antibiotic-treated mice accounted for the accelerated...

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Bibliographische Detailangaben
Hauptverfasser: Heine, Henry S., Louie, Arnold, Adamovicz, Jeffrey J., Amemiya, Kei, Fast, Randy L., Miller, Lynda, Opal, Steven M., Palardy, John, Parejo, Nicolas A., Sörgel, Fritz, Kinzig-Schippers, Martina, Drusano, George L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
Schlagworte:
Experimental Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068467/
https://ncbi.nlm.nih.gov/pubmed/24687492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02420-14
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