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Influence of Friedreich Ataxia GAA Noncoding Repeat Expansions on Pre-mRNA Processing
The intronic GAA repeat expansion in the frataxin (FXN) gene causes the hereditary neurodegenerative disorder Friedreich ataxia. Although it is generally believed that GAA repeats block transcription elongation, direct proof in eukaryotic systems is lacking. We tested in hybrid minigenes the effect...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2443835/ https://ncbi.nlm.nih.gov/pubmed/18597733 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2008.06.018 |
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