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Myosin Regulatory Light Chain Phosphorylation Attenuates Cardiac Hypertrophy

Hyperphosphorylation of myosin regulatory light chain (RLC) in cardiac muscle is proposed to cause compensatory hypertrophy. We therefore investigated potential mechanisms in genetically modified mice. Transgenic (TG) mice were generated to overexpress Ca(2+)/calmodulin-dependent myosin light chain...

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Bibliografiske detaljer
Main Authors: Huang, Jian, Shelton, John M., Richardson, James A., Kamm, Kristine E., Stull, James T.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2443673/
https://ncbi.nlm.nih.gov/pubmed/18474588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802605200
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