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Loss of Neuroprotective Survival Signal in Mice Lacking Insulin Receptor Gene in Rod Photoreceptor Cells

Insulin receptor (IR) signaling provides a trophic signal for transformed retinal neurons in culture, but the role of IR activity in vivo is unknown. We previously reported that light causes increased tyrosine phosphorylation of the IR in vivo, which leads to the downstream activation of the phospho...

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Bibliografiske detaljer
Main Authors: Rajala, Ammaji, Tanito, Masaki, Le, Yun Z., Kahn, C. Ronald, Rajala, Raju V. S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2443670/
https://ncbi.nlm.nih.gov/pubmed/18480052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802374200
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