Structural Determinants of Opioid Activity in Derivatives of 14-Aminomorphinones: Effect of Substitution in the Aromatic Ring of Cinnamoylaminomorphinones and codeinones

In recent years there has been substantial interest in the 14-aminodihydromorphinone derivatives methoclocinnamox (MC-CAM) and clocinnamox (C-CAM). In order to investigate the importance of the cinnamoyl ring substituent a series of analogues have been prepared with chloro, methyl and nitro-substitu...

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Autores principales: Nieland, Nick P.R., Moynihan, Humphrey A., Carrington, Simon, Broadbear, Jillian, Woods, James H., Traynor, John R., Husbands, Stephen M., Lewis, John W.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2006
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2443285/
https://ncbi.nlm.nih.gov/pubmed/16913723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm0604777
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