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Positional stability of single double-strand breaks in mammalian cells

Formation of cancerous translocations requires the illegitimate joining of chromosomes containing double-strand breaks (DSBs). It is unknown how broken chromosome ends find their translocation partners within the cell nucleus. Here, we have visualized and quantitatively analysed the dynamics of sing...

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Bibliografische gegevens
Hoofdauteurs: Soutoglou, Evi, Dorn, Jonas F., Sengupta, Kundan, Jasin, Maria, Nussenzweig, Andre, Ried, Thomas, Danuser, Gaudenz, Misteli, Tom
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2007
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442898/
https://ncbi.nlm.nih.gov/pubmed/17486118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1591
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