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The PPAR-γ Agonist 15-Deoxy-Δ (12,14)-Prostaglandin J(2) Attenuates Microglial Production of IL-12 Family Cytokines: Potential Relevance to Alzheimer's Disease

Accumulation of amyloid-β peptide (Aβ) appears to contribute to the pathogenesis of Alzheimer's disease (AD). Therapeutic hope for the prevention or removal of Aβ deposits has been placed in strategies involving immunization against the Aβ peptide. Initial Aβ immunization studies in animal mode...

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Autors principals: Xu, Jihong, Barger, Steven W., Drew, Paul D.
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2008
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442897/
https://ncbi.nlm.nih.gov/pubmed/18615183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2008/349185
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