CNI-1493 inhibits Aβ production, plaque formation, and cognitive deterioration in an animal model of Alzheimer's disease

Alzheimer's disease (AD) is characterized by neuronal atrophy caused by soluble amyloid β protein (Aβ) peptide “oligomers” and a microglial-mediated inflammatory response elicited by extensive amyloid deposition in the brain. We show that CNI-1493, a tetravalent guanylhydrazone with established...

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Hlavní autoři: Bacher, Michael, Dodel, Richard, Aljabari, Bayan, Keyvani, Kathy, Marambaud, Philippe, Kayed, Rakez, Glabe, Charles, Goertz, Nicole, Hoppmann, Anne, Sachser, Norbert, Klotsche, Jens, Schnell, Susanne, Lewejohann, Lars, Al-Abed, Yousef
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2008
Témata:
Brief Definitive Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442637/
https://ncbi.nlm.nih.gov/pubmed/18573905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20060467
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