CNI-1493 inhibits monocyte/macrophage tumor necrosis factor by suppression of translation efficiency.

Tumor necrosis factor (TNF) mediates a wide variety of disease states including septic shock, acute and chronic inflammation, and cachexia. Recently, a multivalent guanylhydrazone (CNI-1493) developed as an inhibitor of macrophage activation was shown to suppress TNF production and protect against t...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Cohen, P S, Nakshatri, H, Dennis, J, Caragine, T, Bianchi, M, Cerami, A, Tracey, K J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39469/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8632999/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.9.3967
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