Single-stranded DNA-binding Protein in Vitro Eliminates the Orientation-dependent Impediment to Polymerase Passage on CAG/CTG Repeats

Small insertions and deletions of trinucleotide repeats (TNRs) can occur by polymerase slippage and hairpin formation on either template or newly synthesized strands during replication. Although not predicted by a slippage model, deletions occur preferentially when 5′-CTG is in the lagging strand te...

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Bibliographic Details
Main Authors: Delagoutte, Emmanuelle, Goellner, Geoffrey M., Guo, Jie, Baldacci, Giuseppe, McMurray, Cynthia T.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442361/
https://ncbi.nlm.nih.gov/pubmed/18263578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800153200
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