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Proneurotrophins Require Endocytosis and Intracellular Proteolysis to Induce TrkA Activation

The uncleaved, pro-form of nerve growth factor (proNGF) functions as a pro-apoptotic ligand for the p75 neurotrophin receptor (p75NTR). However, some reports have indicated that proneurotrophins bind and activate Trk receptors. In this study, we have examined proneurotrophin receptor binding and act...

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Bibliografske podrobnosti
Main Authors: Boutilier, Jacqueline, Ceni, Claire, Pagdala, Promila C., Forgie, Alison, Neet, Kenneth E., Barker, Philip A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442317/
https://ncbi.nlm.nih.gov/pubmed/18299325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M710018200
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