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Proneurotrophins Require Endocytosis and Intracellular Proteolysis to Induce TrkA Activation
The uncleaved, pro-form of nerve growth factor (proNGF) functions as a pro-apoptotic ligand for the p75 neurotrophin receptor (p75NTR). However, some reports have indicated that proneurotrophins bind and activate Trk receptors. In this study, we have examined proneurotrophin receptor binding and act...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2442317/ https://ncbi.nlm.nih.gov/pubmed/18299325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M710018200 |
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