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Bcl2 Inhibits Abasic Site Repair by Down-regulating APE1 Endonuclease Activity
Bcl2 not only prolongs cell survival but also suppresses the repair of abasic (AP) sites of DNA lesions. Apurinic/apyrimidinic endonuclease 1 (APE1) plays a central role in the repair of AP sites via the base excision repair pathway. Here we found that Bcl2 down-regulates APE1 endonuclease activity...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2442307/ https://ncbi.nlm.nih.gov/pubmed/18263880 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M708345200 |
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