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Effect of a new non-cleavable substrate analog on wild-type and serine mutants in the signature sequence of adenylosuccinate lyase of Bacillus subtilis and Homo sapiens

Adenylosuccinate lyase (ASL) catalyzes two β-elimination reactions in purine biosynthesis, leading to the question of whether the two substrates occupy the same or different active sites. Kinetic studies of Bacillus subtilis and human ASL with a new substrate analog, adenosine phosphonobutyric acid,...

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Bibliografski detalji
Glavni autori: Sivendran, Sharmila, Colman, Roberta F.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2008
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442012/
https://ncbi.nlm.nih.gov/pubmed/18469177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.034777.108
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