Site-specific synthesis of oligonucleotides containing malondialdehyde adducts of deoxyguanosine and deoxyadenosine via a post-synthetic modification strategy

Malondialdehyde (MDA) and its reactive equivalent, base propenal, are products of oxidative damage to lipids and DNA, respectively; they are mutagenic in bacterial and mammalian systems and MDA is carcinogenic in rats. MDA adducts of deoxyguanosine (M(1)dG), deoxyadenosine (OPdA) and deoxycytidine (...

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Autori principali: Wang, Hao, Kozekov, Ivan D., Kozekova, Albena, Tamura, Pamela, Marnett, Lawrence J., Harris, Thomas M., Rizzo, Carmelo J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2006
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2441645/
https://ncbi.nlm.nih.gov/pubmed/17112234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx060137o
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