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Chemical carcinogens in non-enzymatic cytosine deamination: 3-isocyanatoacrylonitrile

Uracil has long been known as the main product of nitrosative cytosine deamination in aqueous solution. Recent mechanistic studies of cytosinediazonium ion suggest that the cation formed by its dediazoniation can ring-open to N-protonated (Z,s-cis)-3-isocyanatoacrylonitrile 7. Stereochemical prefere...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Glaser, Rainer, Wu, Hong, von Saint Paul, Francisca
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer-Verlag 2006
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2441498/
https://ncbi.nlm.nih.gov/pubmed/16411080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00894-005-0048-0
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