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Laforin confers cancer resistance to energy deprivation-induced apoptosis
A long-standing but poorly understood observation in experimental cancer therapy is the heterogeneity in cancer susceptibility to energy deprivation. Here we show that the hexose kinase inhibitor, 2-deoxyl glucose (2-dG), preferentially kills cancer cells with defective Laforin expression and signif...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2440919/ https://ncbi.nlm.nih.gov/pubmed/18519661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-6314 |
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