Laforin Negatively Regulates Cell Cycle Progression through Glycogen Synthase Kinase 3β-Dependent Mechanisms

Glycogen synthase kinase 3β (GSK-3β) represses cell cycle progression by directly phosphorylating cyclin D1 and indirectly regulating cyclin D1 transcription by inhibiting Wnt signaling. Recently, we reported that the Epm2a-encoded laforin is a GSK-3β phosphatase and a tumor suppressor. The cellular...

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Detalhes bibliográficos
Main Authors: Liu, Runhua, Wang, Lizhong, Chen, Chong, Liu, Yan, Zhou, Penghui, Wang, Yin, Wang, Xirui, Turnbull, Julie, Minassian, Berge A., Liu, Yang, Zheng, Pan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593373/
https://ncbi.nlm.nih.gov/pubmed/18824542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01334-08
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