Modes of action of aspirin-like drugs: Salicylates inhibit Erk activation and integrin-dependent neutrophil adhesion

The anti-inflammatory effects of high-dose salicylates are well recognized, incompletely understood and unlikely due entirely to cyclooxygenase (COX) inhibition. We have previously reported a role for activation of the kinase Erk in CD11b/CD18 integrin-dependent adhesiveness of human neutrophils, a...

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Autors principals: Pillinger, Michael H., Capodici, Constance, Rosenthal, Pamela, Kheterpal, Neil, Hanft, Simon, Philips, Mark R., Weissmann, Gerald
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 1998
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC24409/
https://ncbi.nlm.nih.gov/pubmed/9826736
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