Modes of action of aspirin-like drugs: Salicylates inhibit Erk activation and integrin-dependent neutrophil adhesion

The anti-inflammatory effects of high-dose salicylates are well recognized, incompletely understood and unlikely due entirely to cyclooxygenase (COX) inhibition. We have previously reported a role for activation of the kinase Erk in CD11b/CD18 integrin-dependent adhesiveness of human neutrophils, a...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Pillinger, Michael H., Capodici, Constance, Rosenthal, Pamela, Kheterpal, Neil, Hanft, Simon, Philips, Mark R., Weissmann, Gerald
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24409/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9826736/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.24.14540
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