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Dynamic roles of neutrophil extracellular traps in cancer cell adhesion and activation of Notch 1-mediated epithelial-to-mesenchymal transition in EGFR-driven lung cancer cells

IntroductionNeutrophil extracellular traps (NETs) are complex structures released by activated neutrophils that may modulate different steps of the metastatic cascade. The aim of our study was to investigate how NETs can modulate the adhesion properties of cancer cells and whether cell exposure to N...

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Principais autores: Jelena Dimitrov, Maurizio Maddalena, Cristina Terlizzi, Giovanna G. Altobelli, Sara Pellegrino, Tayyaba Mehmood, Viviana De Rosa, Francesca Iommelli, Silvana Del Vecchio
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-10-01
Serier:Frontiers in Immunology
Fag:
neutrophil extracellular traps
epithelial mesenchymal transition
Notch 1
adhesion
migration
tumor microenvironment
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1470620/full
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