THE DIHYDROLIPOAMIDE ACETYLTRANSFERASE IS A NOVEL METABOLIC LONGEVITY FACTOR AND IS REQUIRED FOR CALORIE RESTRICTION MEDIATED LIFE SPAN EXTENSION

Calorie restriction (CR) extends life span in a wide variety of species. Recent studies suggest that an increase in mitochondrial metabolism mediates CR induced life span extension. Here we present evidence that Lat1 (dihydrolipoamide acetyltransferase), the E2 component of the mitochondrial pyruvat...

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Autori principali: Easlon, Erin, Tsang, Felicia, Dilova, Ivanka, Wang, Chen, Lu, Shu-Ping, Skinner, Craig, Lin, Su-Ju
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2440684/
https://ncbi.nlm.nih.gov/pubmed/17200108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M607661200
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