Nutlin-3a Activates p53 to Both Down-regulate Inhibitor of Growth 2 and Up-regulate mir-34a, mir-34b, and mir-34c Expression, and Induce Senescence

Nutlin-3, an MDM2 inhibitor, activates p53, resulting in several types of cancer cells undergoing apoptosis. Although p53 is mutated or deleted in ~50% of all cancers, p53 is still functionally active in the other 50%. Consequently, nutlin-3 and similar drugs could be candidates for neoadjuvant ther...

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Main Authors: Kumamoto, Kensuke, Spillare, Elisa A., Fujita, Kaori, Horikawa, Izumi, Yamashita, Taro, Appella, Ettore, Nagashima, Makoto, Takenoshita, Seiichi, Yokota, Jun, Harris, Curtis C.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2440635/
https://ncbi.nlm.nih.gov/pubmed/18451145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-2780
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