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Caspase Cleavage of HER-2 Releases a Bad-like Cell Death Effector

Human epidermal growth factor receptor-2 (HER-2/ErbB2/neu), a receptor tyrosine kinase that is amplified/overexpressed in poor prognosis breast carcinomas, confers resistance to apoptosis by activating cell survival pathways. Here we demonstrate that the cytoplasmic tail of HER-2 is cleaved by caspa...

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Detalhes bibliográficos
Main Authors: Strohecker, Anne M., Yehiely, Fruma, Chen, Feng, Cryns, Vincent L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2440621/
https://ncbi.nlm.nih.gov/pubmed/18420586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802156200
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