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Caspase Cleavage of HER-2 Releases a Bad-like Cell Death Effector
Human epidermal growth factor receptor-2 (HER-2/ErbB2/neu), a receptor tyrosine kinase that is amplified/overexpressed in poor prognosis breast carcinomas, confers resistance to apoptosis by activating cell survival pathways. Here we demonstrate that the cytoplasmic tail of HER-2 is cleaved by caspa...
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Main Authors: | , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Society for Biochemistry and Molecular Biology
2008
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2440621/ https://ncbi.nlm.nih.gov/pubmed/18420586 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802156200 |
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