Combination of the anti-CD30-auristatin-E antibody-drug conjugate (SGN-35) with chemotherapy improves antitumour activity in Hodgkin lymphoma

The antibody-drug conjugate (ADC) cAC10-vcMMAE consists of the tubulin inhibitor monomethyl auristatin E (MMAE) conjugated to the chimeric anti-CD30 monoclonal antibody cAC10. This ADC potently interferes with the growth of CD30-positive haematological tumours, including Hodgkin lymphoma (HL) and an...

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Dettagli Bibliografici
Autori principali: Oflazoglu, Ezogelin, Kissler, Kim M, Sievers, Eric L, Grewal, Iqbal S, Gerber, Hans-Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2008
Soggetti:
Haematological Malignancy
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2440525/
https://ncbi.nlm.nih.gov/pubmed/18477046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2141.2008.07146.x
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