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Prolonged activation of the N-methyl-d-aspartate receptor–Ca(2+) transduction pathway causes spontaneous recurrent epileptiform discharges in hippocampal neurons in culture

The molecular basis for developing symptomatic epilepsy (epileptogenesis) remains ill defined. We show here in a well characterized hippocampal culture model of epilepsy that the induction of epileptogenesis is Ca(2+)-dependent. The concentration of intracellular free Ca(2+) ([Ca(2+)](i)) was monito...

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Bibliografiske detaljer
Main Authors: DeLorenzo, Robert J., Pal, Shubhro, Sombati, Sompong
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 1998
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC24399/
https://ncbi.nlm.nih.gov/pubmed/9826726
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