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Prolonged activation of the N-methyl-d-aspartate receptor–Ca(2+) transduction pathway causes spontaneous recurrent epileptiform discharges in hippocampal neurons in culture
The molecular basis for developing symptomatic epilepsy (epileptogenesis) remains ill defined. We show here in a well characterized hippocampal culture model of epilepsy that the induction of epileptogenesis is Ca(2+)-dependent. The concentration of intracellular free Ca(2+) ([Ca(2+)](i)) was monito...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC24399/ https://ncbi.nlm.nih.gov/pubmed/9826726 |
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